An improved and simplified method of detecting the acetylator phenotype.
نویسنده
چکیده
A genetic polymorphism has been shown in man for the metabolism of isoniazid (Knight, Selin, and Harris, 1959; Evans, Manley, and McKusick, 1960; Sunahara et al., 1963a, b), and has been shown to control acetylation (Evans, 1962; Jenne, 1963; Evans and White, 1964; Peters, Miller, and Brown, 1965). The acetylation of sulphadimidine (sulfamethazine) has been found to be under the same genetic control as isoniazid (Evans, 1962; Evans and White, 1964; Peters, Gordon, and Brown, 1965). This communication presents evidence that the acetylator phenotype can be simply determined using sulphadimidine as a test drug.
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عنوان ژورنال:
- Journal of medical genetics
دوره 6 4 شماره
صفحات -
تاریخ انتشار 1969